Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC026
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-06-16 06:42
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment Madopar 250mg 3x 1/4

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 2 individuals with a value less than 0.51 were subsequently diagnosed with PD. That is, 4.76% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.51 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 42, 'TN': 30, 'TP': 0, 'FP': 0}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 27, 'TN': 25, 'TP': 15, 'FP': 5}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 41, 'TN': 30, 'TP': 1, 'FP': 0}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 15, 'TN': 9, 'TP': 27, 'FP': 21}

Test Battery Details

Circle

numCircles 11
timePerCircleMean 18.8036
timePerCircleCoV 0.716174
timePerCircleSlope -0.00226262
meanError 3.6968
tremorFreq 5.85938
tremorRelPower 31.5578
tremorGyroAmpMean 0.028377
tremorGyroAmpSlope 0.00330949
tremorGyroAmpCoV 0.575008
tremorCoordAmpMean 0.0456468
tremorCoordAmpSlope -0.000804024
tremorCoordAmpCoV 0.654666
tremorAccAmpMean 0.0595653
tremorAccAmpSlope -0.000110758
tremorAccAmpCoV 0.300981
tremorPcRelVar 0.774458
tremorPcX 0.345244
tremorPcY -0.938513

Circle Segment 1

Duration 11.72 s, Accuracy Estimate 5.332 (lower is better)

Circle Segment 2

Duration 27.72 s, Accuracy Estimate 6.711 (lower is better)

Circle Segment 3

Duration 7.04 s, Accuracy Estimate 3.242 (lower is better)

Circle Segment 4

Duration 19.52 s, Accuracy Estimate 5.022 (lower is better)

Circle Segment 5

Duration 34.8 s, Accuracy Estimate 2.502 (lower is better)

Circle Segment 6

Duration 7.76 s, Accuracy Estimate 2.381 (lower is better)

Circle Segment 7

Duration 13.84 s, Accuracy Estimate 5.088 (lower is better)

Circle Segment 8

Duration 24.96 s, Accuracy Estimate 1.754 (lower is better)

Circle Segment 9

Duration 46.88 s, Accuracy Estimate 2.577 (lower is better)

Circle Segment 10

Duration 7.64 s, Accuracy Estimate 2.704 (lower is better)

Circle Segment 11

Duration 4.96 s, Accuracy Estimate 3.353 (lower is better)

Spiral

numSpirals 9
timePerSpiralMean 26.4089
timePerSpiralCoV 0.652279
timePerSpiralSlope -0.0812353
meanError 3.52822
tremorFreq 5.17578
tremorRelPower 47.8943
tremorGyroAmpMean 0.0497316
tremorGyroAmpSlope 0.00253513
tremorGyroAmpCoV 0.65618
tremorCoordAmpMean 0.060528
tremorCoordAmpSlope 0.000583342
tremorCoordAmpCoV 0.572054
tremorAccAmpMean 0.0539801
tremorAccAmpSlope 0.000150711
tremorAccAmpCoV 0.516652
tremorPcRelVar 0.622369
tremorPcX 0.0215249
tremorPcY 0.999768

Spiral Segment 1

Duration 17.88 s, Accuracy Estimate 2.642 (lower is better)

Spiral Segment 2

Duration 47.0 s, Accuracy Estimate 4.379 (lower is better)

Spiral Segment 3

Duration 39.88 s, Accuracy Estimate 2.319 (lower is better)

Spiral Segment 4

Duration 14.16 s, Accuracy Estimate 5.232 (lower is better)

Spiral Segment 5

Duration 16.48 s, Accuracy Estimate 4.62 (lower is better)

Spiral Segment 6

Duration 56.56 s, Accuracy Estimate 2.382 (lower is better)

Spiral Segment 7

Duration 20.8 s, Accuracy Estimate 3.121 (lower is better)

Spiral Segment 8

Duration 20.12 s, Accuracy Estimate 2.862 (lower is better)

Spiral Segment 9

Duration 4.8 s, Accuracy Estimate 4.196 (lower is better)

Elel

eDurationMean 0.756842
eDurationStd 0.461681
eDurationStdnorm 0.610009
eDurationMedian 0.6075
eDurationQuartdelta 0.425
eDurationQuartdeltanorm 0.699588
eDurationKurt 8.50885
eDurationTrenddiff -0.135
eDurationTrendratio 0.805755
eWidthMean 9.77974
eWidthStd 3.88286
eWidthStdnorm 0.397031
eWidthMedian 8.8335
eWidthQuartdelta 5.616
eWidthQuartdeltanorm 0.635762
eWidthKurt 3.6585
eWidthTrenddiff 2.86292
eWidthTrendratio 1.36779
eHeightMean 13.6398
eHeightStd 4.54841
eHeightStdnorm 0.333466
eHeightMedian 14.9175
eHeightQuartdelta 6.59464
eHeightQuartdeltanorm 0.442074
eHeightKurt 3.03363
eHeightTrenddiff 3.861
eHeightTrendratio 1.31132
eAspectMean 0.781283
eAspectStd 0.357256
eAspectStdnorm 0.457268
eAspectMedian 0.696987
eAspectQuartdelta 0.339286
eAspectQuartdeltanorm 0.486789
eAspectKurt 4.77159
eAspectTrenddiff 0.0412037
eAspectTrendratio 1.06087
eSlantMean -0.0132863
eSlantStd 0.325834
eSlantStdnorm -24.5241
eSlantMedian -0.0581062
eSlantQuartdelta 0.430963
eSlantQuartdeltanorm -7.41682
eSlantKurt 2.6972
eSlantTrenddiff -0.103676
eRtopMean 0.596974
eRtopStd 0.221873
eRtopStdnorm 0.371663
eRtopMedian 0.603446
eRtopQuartdelta 0.306543
eRtopQuartdeltanorm 0.507986
eRtopKurt 2.93963
eRtopTrenddiff -0.0153366
eRbotMean 0.65608
eRbotStd 0.363706
eRbotStdnorm 0.554363
eRbotMedian 0.612227
eRbotQuartdelta 0.446664
eRbotQuartdeltanorm 0.729572
eRbotKurt 4.26414
eRbotTrenddiff 0.00965191
eRrightMean 0.651612
eRrightStd 0.403876
eRrightStdnorm 0.619811
eRrightMedian 0.759491
eRrightQuartdelta 0.306793
eRrightQuartdeltanorm 0.403946
eRrightKurt 21.9866
eRrightTrenddiff -0.0640609
eRleftMean 0.460509
eRleftStd 0.222037
eRleftStdnorm 0.482155
eRleftMedian 0.458196
eRleftQuartdelta 0.304811
eRleftQuartdeltanorm 0.665242
eRleftKurt 2.747
eRleftTrenddiff -0.0154934
lDurationMean 0.725
lDurationStd 0.448982
lDurationStdnorm 0.619285
lDurationMedian 0.64
lDurationQuartdelta 0.3
lDurationQuartdeltanorm 0.46875
lDurationKurt 16.166
lDurationTrenddiff -0.165
lDurationTrendratio 0.75188
lWidthMean 10.9037
lWidthStd 4.73894
lWidthStdnorm 0.434616
lWidthMedian 10.413
lWidthQuartdelta 5.733
lWidthQuartdeltanorm 0.550562
lWidthKurt 3.83177
lWidthTrenddiff -2.223
lWidthTrendratio 0.824074
lHeightMean 19.8622
lHeightStd 7.38413
lHeightStdnorm 0.371769
lHeightMedian 20.943
lHeightQuartdelta 14.8008
lHeightQuartdeltanorm 0.706718
lHeightKurt 1.67901
lHeightTrenddiff 0.735481
lHeightTrendratio 1.03619
lAspectMean 0.594772
lAspectStd 0.275632
lAspectStdnorm 0.463425
lAspectMedian 0.523393
lAspectQuartdelta 0.33123
lAspectQuartdeltanorm 0.632851
lAspectKurt 5.67517
lAspectTrenddiff -0.191002
lAspectTrendratio 0.702702
lSlantMean -0.0227461
lSlantStd 0.269781
lSlantStdnorm -11.8605
lSlantMedian 0.0293688
lSlantQuartdelta 0.308422
lSlantQuartdeltanorm 10.5017
lSlantKurt 2.48389
lSlantTrenddiff 0.0803409
lRtopMean 0.719715
lRtopStd 0.189941
lRtopStdnorm 0.263911
lRtopMedian 0.758021
lRtopQuartdelta 0.234053
lRtopQuartdeltanorm 0.308769
lRtopKurt 2.75428
lRtopTrenddiff 0.127163
lRbotMean 0.822178
lRbotStd 0.693978
lRbotStdnorm 0.844073
lRbotMedian 0.678279
lRbotQuartdelta 0.455003
lRbotQuartdeltanorm 0.67082
lRbotKurt 19.0946
lRbotTrenddiff -0.0312538
lRrightMean 0.822188
lRrightStd 0.134904
lRrightStdnorm 0.164079
lRrightMedian 0.861129
lRrightQuartdelta 0.199516
lRrightQuartdeltanorm 0.231691
lRrightKurt 2.28062
lRrightTrenddiff -0.0198747
lRleftMean 0.398976
lRleftStd 0.184155
lRleftStdnorm 0.461569
lRleftMedian 0.356419
lRleftQuartdelta 0.281177
lRleftQuartdeltanorm 0.788894
lRleftKurt 2.3275
lRleftTrenddiff -0.0934252

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

Elel Segment 14

Elel Segment 15

Elel Segment 16

Elel Segment 17

Elel Segment 18

Elel Segment 19

Elel Segment 20

Elel Segment 21

FITTS Short Modified

meanTouchScore 0.659831
sumTouchScores 9.89746
meanMovementTime 0.972143
numTouches 15
undershootPercentage 6.66667
overshootPercentage 33.3333

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.584675
sumTouchScores 4.09273
meanMovementTime 2.85333
numTouches 7
undershootPercentage 0
overshootPercentage 42.8571

ZigZag

numZigzags 3
timePerZigzagMean 56.2
timePerZigzagCoV 0.275465
timePerZigzagSlope 0.109609
meanError 2.70149
tremorFreq 5.37109
tremorRelPower 30.9598
tremorGyroAmpMean 0.04241
tremorGyroAmpSlope 0.0031937
tremorGyroAmpCoV 0.62195
tremorCoordAmpMean 0.0853277
tremorCoordAmpSlope 0.00200883
tremorCoordAmpCoV 0.516924
tremorAccAmpMean 0.0748246
tremorAccAmpSlope 0.00194994
tremorAccAmpCoV 0.479719
tremorPcRelVar 0.866322
tremorPcX 0.264979
tremorPcY -0.964254

ZigZag Segment 1

Duration 58.24 s, Accuracy Estimate 2.314 (lower is better)

ZigZag Segment 2

Duration 39.8 s, Accuracy Estimate 2.594 (lower is better)

ZigZag Segment 3

Duration 70.56 s, Accuracy Estimate 3.196 (lower is better)

ZigZag Offset

numZigzags 9
timePerZigzagMean 8.52889
timePerZigzagCoV 0.300301
timePerZigzagSlope 0.0288431
zigzagHeightMean 54.8131
zigzagHeightCoV 0.163344
zigzagHeightSlope 0.0226241
meanError 0.0673265
tremorFreq 5.66406
tremorRelPower 34.4495
tremorGyroAmpMean 0.0976187
tremorGyroAmpSlope 0.000271934
tremorGyroAmpCoV 0.390102
tremorCoordAmpMean 0.204471
tremorCoordAmpSlope 0.00021232
tremorCoordAmpCoV 0.446138
tremorAccAmpMean 0.199653
tremorAccAmpSlope 0.000650174
tremorAccAmpCoV 0.378839
tremorPcRelVar 0.946387
tremorPcX -0.375481
tremorPcY -0.92683

ZigZag Offset Segment 1

Duration 7.24 s, Accuracy Estimate 0.058 (lower is better)

ZigZag Offset Segment 2

Duration 5.84 s, Accuracy Estimate 0.098 (lower is better)

ZigZag Offset Segment 3

Duration 10.8 s, Accuracy Estimate 0.054 (lower is better)

ZigZag Offset Segment 4

Duration 9.56 s, Accuracy Estimate 0.048 (lower is better)

ZigZag Offset Segment 5

Duration 8.0 s, Accuracy Estimate 0.043 (lower is better)

ZigZag Offset Segment 6

Duration 7.8 s, Accuracy Estimate 0.048 (lower is better)

ZigZag Offset Segment 7

Duration 5.8 s, Accuracy Estimate 0.066 (lower is better)

ZigZag Offset Segment 8

Duration 13.88 s, Accuracy Estimate 0.112 (lower is better)

ZigZag Offset Segment 9

Duration 7.84 s, Accuracy Estimate 0.078 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.76}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.51}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.9956684084065242}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.7987428156816685}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.7740070014563843}